一种基于亲水性聚合物和药物的自组装体系统及其制备方法技术方案

本发明专利技术涉及一种基于亲水性聚合物和药物的自组装体系统及其制备方法。该系统由亲水性聚合物和含有羧基的药物组成；其中亲水性聚合物为聚乙烯亚胺或β-环糊精改性的聚乙烯亚胺；含有羧基的药物选自布洛芬、酮洛芬、非诺洛芬、氟比洛芬、奥沙普秦、萘普生、吲哚美辛、舒林酸、依托度酸、双氯芬酸、甲灭酸、甲氯芬那酸、氟芬那酸、托灭酸、罗美昔布、利克飞龙、二氟尼柳、阿司匹林。制备时，首先将亲水性聚合物溶于一定量水中，再将药物溶于水溶性有机溶剂中，然后将溶有药物的有机溶液在超声作用下缓慢加入聚合物水溶液中；之后将该混合液置于透析袋中，磁力搅拌下在去离子水中透析，一定时间间隔更换去离子水；5～48h后过滤透析液，冷冻干燥即得。

Self assembly system based on hydrophilic polymer and medicine and preparation method thereof

The present invention relates to a self-assembly system based on hydrophilic polymers and drugs and a method for preparing the same. The system is composed of a hydrophilic polymer and a carboxyl group containing drug composition; wherein the hydrophilic polymer polyethyleneimine polyethylene imine or beta cyclodextrin modified carboxyl containing drugs; from Bloven, ketoprofen and fenoprofen, flurbiprofen, naproxen, indomethacin, oxaprozin, sulindac, etodolac, diclofenac, a mefenamic acid, Meclofenamic acid, flufenamic acid, tolfenamic acid, lumiracoxib, licofelone, two diflunisal, aspirin. During the preparation of the hydrophilic polymer is dissolved in a certain amount of water, then the medicine is dissolved in water soluble organic solvent, and then dissolved organic drug solution under ultrasound slowly adding aqueous polymer solution; then the mixed solution in the dialysis bag, magnetic stirring in deionized water for dialysis, certain the time interval of deionized water; 5 ~ 48h after filtration dialysis solution, freeze drying to obtain.

【技术实现步骤摘要】

【技术保护点】
一种基于亲水性聚合物和药物的自组装体系统，其特征在于：该自组装体系统由亲水性聚合物和含有羧基的药物组成；所述含有羧基的药物与亲水性聚合物的质量比为０．０１∶１～８∶１。

【技术特征摘要】

【专利技术属性】
技术研发人员：李晓辉，张建祥，李淑慧，
申请(专利权)人：李晓辉，张建祥，李淑慧，
类型：发明
国别省市：85