【技术实现步骤摘要】
一组左眼柱镜数量性状相关的SNP标志物及其应用
[0001]本专利技术属于生物医药领域,涉及一组左眼柱镜数量性状相关的SNP标志物及其应用。
技术介绍
[0002]眼科疾病是指发生在眼部区域的疾病,常见眼科疾病有近视、散光、白内障、青光眼、中心浆液性视网膜病变、干眼症、交感性眼炎、夜盲症、弱视、沙眼、糖尿病视网膜病变、结膜炎、老花眼、色盲、视网膜色素变性、视网膜中央动脉阻塞、视网膜脱落、远视、针眼、雪盲症、霰粒肿、飞蚊症等。在调节放松的状态下,平行光线经眼球屈光系统后聚焦在视网膜之前,称为近视。
[0003]屈光度是指屈光不正状态下所产生的度数大小,当屈光度发生时,一般多代表近视、散光、远视或是弱视等临床表现,近视、远视通常为球镜(S),散光为柱镜(C),目前采用等效球镜度数(Spherical Equivalent Refraction,SE)评价屈光度,等效球镜度数=球镜度数+散光度数*1/2。屈光度≤
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0.50D可作为近视诊断的循证共识阈值。更具体地,近视的定义是当调节放松时,眼睛的等效球镜屈光不正≤
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0.5D的情况。高度近视的定义是当调节放松时,眼睛的等效球镜屈光不正≤
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6.00D的情况。低度近视的定义是当调节放松时,眼睛的等效球镜屈光不正≤
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0.5且>
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6.00D的情况。
[0004]近视作为一种全球高发性疾病近年来受到国内外越来越多的关注,预计到2050年,近视将影响到全球近5 ...
【技术保护点】
【技术特征摘要】
1.一种用于诊断近视的生物标志物,其特征在于,所述生物标志物与左眼柱镜相关。2.根据权利要求1所述的生物标志物,其特征在于,所述生物标志物包括以下任一组:1)rs26173、rs26098、rs26107、rs26086、rs143580489、rs10484690、rs117984746;2)rs2296474、rs2765015、rs3766165、rs145378993、rs13306137、rs147707514、rs112218972、rs3796381、rs26173、rs26098、rs26107、rs26086、rs987106、rs75126858、rs61734326、rs2278226、rs6928630、rs143580489、rs1204114、rs10484690、rs74699763、rs11574345、rs4925828、rs304494、rs304439、rs304448、rs4763975、rs377238277、rs144650014、rs12438118、rs41303763、rs9797618、rs10420552、rs4802029、rs28512414、rs1975937、rs2075284、rs3095726、rs34785154、rs60704260、rs6084431、rs147911723、rs41279352、rs2427624、rs117984746;3)rs2296474、rs307377、rs2765015、rs3766165、rs145378993、rs61746709、rs114369626、rs4147830、rs540468026、rs80105432、rs45445497、rs13306137、rs191506876、rs147707514、rs4149520、rs4988956、rs4988957、rs10192036、rs10204137、rs4988958、rs10192157、rs10206753、rs3755276、rs112218972、rs3749022、rs76999397、rs35220123、rs80341144、rs3796381、rs117486807、rs147434354、rs76469954、rs26173、rs26098、rs26107、rs26086、rs987106、rs75126858、rs61734326、rs2278226、rs144289000、chr5
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140568680、rs7701410、rs117600221、rs150856424、rs3188、rs6928630、rs143580489、rs1204114、rs10484690、rs775410128、rs13225910、rs61733329、rs189212243、rs74699763、rs11574345、rs8178175、rs10092164、rs11539113、rs68008113、rs7462883、rs66881636、rs61747644、rs2721167、rs2620644、rs2250891、rs2250657、rs2721176、rs4925828、rs117569740、rs142643091、rs140966742、rs3758464、rs16935560、rs144762118、rs7899453、rs3740252、rs304494、rs304439、rs304448、rs148238084、rs622082、rs546382、rs189385634、rs4763975、rs2232566、rs7132546、rs5742612、rs35767、rs2861550、rs377238277、rs144650014、rs35405829、rs11569599、rs10130914、rs140879339、rs12438118、rs182015467、rs41303763、rs142805492、rs8055740、rs75743672、rs75277269、rs76896732、rs2164449、rs2230601、rs9303742、rs79577494、rs9797618、rs10420552、rs4802029、rs28512414、rs1975937、rs958305、rs2075284、rs3095726、rs34785154、rs60704260、rs2034891、rs117753855、rs78472358、rs8099961、rs58634535、rs6084431、rs147911723、rs41279352、rs2427624、rs117984746、rs470101、rs2267163;4)rs6690013、rs609805、rs621668、rs2274264、rs2274263、rs2296474、rs10907179、rs307349、rs307355、rs35744813、rs307377、rs307371、rs2296471、rs2765015、rs34091023、rs1171、rs3766165、rs145378993、rs115226069、rs61746709、rs2274329、rs2274330、rs3765967、rs148750290、rs114369626、rs35533335、rs74622002、rs145619910、rs141216171、rs146227933、rs145717494、rs4147830、rs3215952、rs2229783、rs17127203、rs1676486、rs1763347、rs368345074、rs7556386、rs540468026、rs374309842、rs942963、rs77181873、rs80105432、rs33941127、rs45445497、rs12026637、rs144649977、rs78780269、rs3813972、rs60555365、rs335524、rs4149230、rs2292559、rs2292561、rs41310561、rs147519768、rs13306137、rs1800672、rs2296801、rs77082151、
rs76255469、rs12135078、rs112212885、rs62121538、rs191506876、rs147707514、rs74867758、rs4665385、rs3792253、rs1126497、rs4149520、rs3771175、rs4988956、rs4988957、rs10192036、rs10204137、rs4988958、rs10192157、rs10206753、rs3755276、rs112218972、rs116177854、rs2123465、rs2116664、rs1469651、rs1469650、rs1053394、rs77698806、rs1434087、rs3749022、rs145346406、rs6734083、rs11676792、rs53576、rs76999397、rs2075310、rs35993975、rs33917318、rs17032276、rs17032278、rs17032283、rs35220123、rs9879080、rs7649243、rs34608006、rs6805869、rs9811771、rs2272125、rs2272124、rs7626117、rs7647987、rs6796538、rs35229877、rs11919713、rs1969154、rs1985428、rs3732675、rs80341144、rs181735010、rs3796381、rs76407344、rs11719458、rs2292661、rs79845192、rs74682201、rs77220512、rs35070271、rs79144888、rs76371354、rs78233713、rs117486807、rs147434354、rs6815254、rs3756247、rs1457976435、rs191674075、rs3749584、rs10517195、rs78205702、rs76469954、rs26173、rs26098、rs26107、rs26086、rs987106、rs62387135、rs79420400、rs75126858、rs61734326、rs2278226、rs2228112、rs42688、rs32210、rs6886922、rs118179072、rs144289000、chr5
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140568680、rs182889312、rs7701410、rs117600221、rs142883877、r...
【专利技术属性】
技术研发人员:王宏,徐良德,
申请(专利权)人:温州眼视光国际创新中心,
类型:发明
国别省市:
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