【技术实现步骤摘要】
一种用于预测子痫前期风险的基因组合、子痫前期风险预测模型及其构建方法
本专利技术属于生物医学
,具体涉及一种用于预测子痫前期风险的基因组合、子痫前期风险预测模型及其构建方法。
技术介绍
子痫前期是指妊娠20周以后,出现血压升高和蛋白尿,并可出现头痛、眼花、恶心、呕吐、上腹不适等症状。子痫是由子痫前期发展成更为严重的症状,引起抽搐发作或昏迷,可导致严重的母儿并发症。子痫前期的发生率约为孕妇的5-10%,初产妇、有高血压及血管疾病的孕妇更为常见。子痫前期根据发病时间的早晚,分为早发型和晚发型子痫前期。早发型子痫前期是指在妊娠34周前发病的子痫前期,由于发病早,胎儿尚未成熟,因此对孕产妇的影响尤为严重。由于子痫前期和子痫的病因尚不清楚,多因素在其中发挥作用,主要包括遗传因素、营养、免疫、代谢、生活习惯等,是一种环境与遗传多因素共同发挥作用的疾病。一项超过32000名女性参与的的荟萃分析结果证实,在对于本病高风险人群,在妊娠中期口服阿司匹林可以降低15%的发病风险,也是防治本病的一个重要突破口。显然,单纯依赖阿司匹林并不能完全预防本病的发生。因此从多角度挖掘本病的致病原因,针对于每个个体进行个性化综合评估,在疾病发生之前进行准确的预测高危人群,成为高危产科医生近年来研究的热点。子痫前期的遗传易感性在国内外均有报道,其中较为常见的表现是基因多态性变化。基因多态性是指在一个生物群体中,同时和经常存在两种或多种不连续的变异型或基因型(genotype)或等位基因(allele),亦称遗传多态性(genetic ...
【技术保护点】
1.一种用于预测子痫前期风险的基因组合,其特征在于,包括499个SNP位点,分别为:rs1111875、rs3764650、rs890293、rs4934、rs2230806、rs405509、rs12983082、rs2516049、rs10830963、rs2000813、rs7202116、rs3764261、rs7079、rs1805094、rs8178847、rs1421811、rs715987、rs8096897、rs574957、rs10744835、rs1991391、rs7977406、rs11066188、rs2036914、rs8099917、rs12979860、rs10048158、rs1801689、rs9264942、rs9277535、rs2523393、rs2230204、rs7107152、rs12086634、rs1242229、rs2236242、rs3779512、rs1864163、rs1549758、rs5491、rs7578597、rs7209395、rs6042935、rs121912702、rs155524、rs7640747、rs7 ...
【技术特征摘要】
1.一种用于预测子痫前期风险的基因组合,其特征在于,包括499个SNP位点,分别为:rs1111875、rs3764650、rs890293、rs4934、rs2230806、rs405509、rs12983082、rs2516049、rs10830963、rs2000813、rs7202116、rs3764261、rs7079、rs1805094、rs8178847、rs1421811、rs715987、rs8096897、rs574957、rs10744835、rs1991391、rs7977406、rs11066188、rs2036914、rs8099917、rs12979860、rs10048158、rs1801689、rs9264942、rs9277535、rs2523393、rs2230204、rs7107152、rs12086634、rs1242229、rs2236242、rs3779512、rs1864163、rs1549758、rs5491、rs7578597、rs7209395、rs6042935、rs121912702、rs155524、rs7640747、rs7926335、rs743395、rs1800206、rs11977526、rs3804099、rs1799750、rs1049337、rs28362491、rs10120688、rs1051740、rs2167270、rs7804372、rs11568821、rs12203592、rs1799724、rs1805192、rs2066847、rs1800451、rs5030737、rs4766578、rs4149056、rs4675378、rs281874770、rs4321325、rs11018628、rs1800794、rs1805010、rs780093、rs3853839、rs7805969、rs7574865、rs8178822、rs333、rs2384550、rs925489、rs57659670、rs853326、rs180223、rs1472565、rs2596623、rs231779、rs4850755、rs6885099、rs1800693、rs2046045、rs4704397、rs1137617、rs10733113、rs653178、rs10774625、rs2517532、rs9910950、rs8178848、rs16950081、rs4925295、rs963167、rs2647528、rs2319125、rs4581、rs2288493、rs79154414、rs2277698、rs2279744、rs2217332、rs8178819、rs6906021、rs2736340、rs4915077、rs1523127、rs1554973、rs17145713、rs1041981、rs11538264、rs204999、rs2476601、rs6457452、rs9277534、rs3099844、rs4149584、rs492899、rs17630235、rs9322331、rs556442、rs3890182、rs10938397、rs4773724、rs1275988、rs1558902、rs1800437、rs17577、rs13385、rs2074311、rs642858、rs11651270、rs2237895、rs231840、rs1799999、rs2292239、rs7163757、rs2670660、rs11066280、rs7178572、rs4721、rs391300、rs4828038、rs7713645、rs3087243、rs17817449、rs455060、rs2075290、rs13702、rs3021094、rs1260326、rs2237892、rs1550805、rs6259、rs2083637、rs2779248、rs1137933、rs3847987、rs77060950、rs7709243、rs7770619、rs1801278、rs7903146、rs4506565、rs17681684、rs17696736、rs1050828、rs231357、rs199972616、rs4416547、rs10509305、rs12762303、rs2280275、rs2014408、rs1532624、rs3746429、rs1926723、rs11105354、rs7439293、rs445925、rs3850641、rs7194256、rs867186、rs3184504、rs5743293、rs825476、rs7580658、rs1801693、rs854560、rs1056917、rs61996318、rs9898、rs13146272、rs4311994、rs1654433、rs11105357、rs4148189、rs4576240、rs11751198、rs11968400、rs11970154、rs12210887、rs13118、rs2075015、rs2285321、rs2394392、rs2508015、rs2523995、rs2524272、rs25527、rs28986465、rs29243、rs3130663、rs3130685、rs3132584、rs64036、rs6457254、rs6924270、rs6933400、rs6937357、rs73055442、rs7749235、rs9261800、rs9267547、rs9468805、rs9500864、rs1441756、rs15285、rs9941065、rs2596574、rs11085421、rs3785617、rs78010183、rs2292354、rs289717、rs247616、rs879922、rs1799945、rs2097055、rs662、rs1532085、rs3757354、rs3813082、rs326、rs662799、rs12597002、rs4131229、rs964184、rs13105517、rs1260333、rs2075291、rs5104、rs670、rs17482753、rs2043085、rs4969168、rs7350481、rs12678919、rs6671879、rs4743771、rs328、rs285、rs6720173、rs10096633、rs301、rs1003723、rs2303790、rs2266788、rs429358、rs10503669、rs1051931、rs7756935、rs10790162、rs5174、rs562556、rs4253728、rs2269702、rs66698963、rs9326246、rs7016880、rs1801394、rs1805087、rs9852991、rs12230074、rs9815354、rs6768438、rs957525、rs9816772、rs11024074、rs10506974、rs3754777、rs1173771、rs13394970、rs17249754、rs176185、rs2070759、rs6410、rs11105378、rs2586886、rs2004776、rs11191548、rs35444、rs6433027、rs3749585、rs16998073、rs1378942、rs2681492、rs6495122、rs12413409、rs7726475、rs5049、rs1401982、rs1105378、rs16948048、rs11014166、rs11568020、rs381815、rs11065987、rs1131882、rs11572325、rs880315、rs4612666、rs651007、rs671、rs10507391、rs3135506、rs10743565、rs1426409、rs193921036、rs200898934、rs201223301、rs374976508、rs7080、rs2237076、rs3765407、rs3820059、rs9831647、rs1862176、r...
【专利技术属性】
技术研发人员:陈颖,左红斌,魏本杰,马玲玉,丛华剑,杜昭励,王合,于沛勇,苏鹤,杨海燕,
申请(专利权)人:吉林大学,吉林省银丰生物工程技术有限公司,
类型:发明
国别省市:吉林;22
还没有人留言评论。发表了对其他浏览者有用的留言会获得科技券。