The invention relates to a traditional Chinese medicine compound preparation for treating viral myocarditis in children and its preparation process, belonging to the technical field of medical use of the effective parts of traditional Chinese medicine. The technical scheme is as follows: crushing American ginseng into coarse particles, adding ethanol and heating reflux to extract for three times. The extracted filtrate is concentrated by rotary evaporator. The concentrated filtrate is extracted by petroleum ether and water saturated n-butanol for three times. The supernatant is extracted by rotary evaporator, and n-butanol in the supernatant is recovered by rotary evaporator. The remaining medicinal liquid is evaporated by water bath. After concentration, the total American ginseng is dried in the drying chamber. The preparation methods of total saponins of Astragalus membranaceus, Paeonia suffruticosa and Wangbuliuxing are the same; the proportion of components allocation: total saponins of Panax quinquefolium, Astragalus membranaceus, Paeonia suffruticosa and Wangbuliuxing is 6:6:4:1. The raw material medicine of the invention has wide source, low cost, remarkable pharmacodynamics, safety and non-toxicity, small dosage, convenient for children to take, oral medicine and convenient storage.
【技术实现步骤摘要】
一种治疗小儿病毒性心肌炎的中药复方制剂及其制备工艺
本专利技术涉及一种治疗小儿病毒性心肌炎的中药复方制剂及其制备工艺,特别是肠道病毒中柯萨奇病毒B组病毒(CoxsackievirusB,CVB)引起的心肌组织损伤及心肌细胞凋亡中的应用,属于中药有效部位的医药用途
技术介绍
病毒性心肌炎(Viralmyocarditis,VMC)是指病毒感染引起的心肌局限性或弥漫性的急性或慢性炎症病变,属于感染性心肌疾病。VMC患病人群广泛,以学龄前儿童及学龄儿童多见,多数由肠道病毒及呼吸道病毒引发。柯萨奇病毒A组、柯萨奇病毒B组(CoxsackievirusB,CVB)、艾可病毒、脊髓灰质炎病毒是常见致心肌炎致病病毒,其中CVB是最主要的病原体,发病率约占30%~50%,CVB包括六种血清型,其中B3型致病性最强,易造成重症和死亡病例,是我国病毒性心肌炎患儿的主要致病病毒。人类感染CVB后,约有5~7%发生心肌炎,部分病例可发展为扩张型心肌病(Dilatedcardiomyopathy,DCM),遗留心功能不全等后遗症,严重者需要心脏移植。在法医猝死案例中,VMC和DCM的猝死率仅次于冠心病和高血压,位于心性猝死的第三位。近年来儿童和青少年中VMC的发病率呈明显上升趋势,占到了青少年猝死的10%~44%,已成为儿童和青少年猝死的一个重要原因,引起了医学界的广泛重视。VMC治疗药物种类有限,专门针对小儿病毒性心肌炎的治疗药物更是缺乏,亟需开发新的治疗药物。西药治疗主要针对病毒感染和心肌炎症对症治疗,但效果均不理想,常有不同程度的不良反应,且价格昂贵。中药文献虽记载 ...
【技术保护点】
1.一种治疗小儿病毒性心肌炎的中药复方制剂,其特征在于该中药复方制剂是由下述原料药物制成:西洋参总皂苷、黄芪总皂苷、牡丹皮总皂苷和王不留行总皂苷,上述原料药物的质量比为6:6:4:1。
【技术特征摘要】
1.一种治疗小儿病毒性心肌炎的中药复方制剂,其特征在于该中药复方制剂是由下述原料药物制成:西洋参总皂苷、黄芪总皂苷、牡丹皮总皂苷和王不留行总皂苷,上述原料药物的质量比为6:6:4:1。2.一种治疗小儿病毒性心肌炎的中药复方制剂的制备工艺,其特征在于如下工艺步骤:步骤一:有效组分的制备将西洋参粉碎成粗颗粒,加入乙醇加热回流提取3次,提取后的滤液用...
【专利技术属性】
技术研发人员:姚荣妹,张之斌,马会霞,包巨太,
申请(专利权)人:华北理工大学,
类型:发明
国别省市:河北,13
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