3-氟代烷基-1-甲基吡唑-4-羧酸的制备方法技术

本发明专利技术涉及一种3‑氟代烷基‑1‑甲基吡唑‑4‑羧酸的制备方法，包括以下步骤：步骤一、以式I所示的氟代乙酰卤衍生物与二甲胺基乙烯基甲基酮缩合反应，生成式II所示的3‑二甲胺基亚甲基‑1,1‑二氟代‑2,4‑戊二酮衍生物；步骤二、以所述式II所示的3‑二甲胺基亚甲基‑1,1‑二氟代‑2,4‑戊二酮衍生物与甲基肼关环反应，生成式III所示的3‑氟代烷基‑1‑甲基‑4‑乙酰基吡唑衍生物；步骤三、以所述式III所示的3‑氟代烷基‑1‑甲基‑4‑乙酰基吡唑衍生物在碱性条件下氧化，再酸化，生成式IV所示的3‑氟代烷基‑1‑甲基吡唑‑4‑羧酸。本发明专利技术的制备方法反应路线较短，原料成本较低，各步骤反应收率高，适于工业化生产。

Preparation of 3- fluoroalkyl -1- methyl pyrazole -4- carboxylic acid

The invention relates to a preparation method of 3 fluoroalkyl 1 methyl pyrazole 4 carboxylic acid, including the following steps: Step 1, the condensation reaction of fluoroacetyl halogen derivative with two methylamine methyl methyl ketone, as shown by I, and the generation type II methylamine methylamine 1,1 two fluoro two fluoroacetone derivative Step two, the reaction of the 3, two methylamimyl methylene glycol, two fluoroacetone derivative and the methyl hydrazine ring, shown by the type of II, is produced by the formation III of the 3 fluoroalkyl 1 alkyl 4 acetyl acetyl pyrazole derivatives; step three, as shown by the III, the 3 fluoroalkyl 1 methyl 4 methyl 4 acetyl The derivatives of pyrazole are oxidized and acidified under alkaline conditions to form 3_fluoroalkyl_1_methylpyrazole_4_carboxylicacid as shown in formula IV. The preparation method of the invention has shorter reaction route, lower raw material cost, higher reaction yield in each step, and is suitable for industrial production.

【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请，说明书已公开。

【技术保护点】
PCT国内申请，权利要求书已公开。

【技术特征摘要】
【国外来华专利技术】2015.09....

【专利技术属性】
技术研发人员：王明春，李庆毅，
申请(专利权)人：苏威氟有限公司，常州市卜弋科研化工有限公司，
类型：发明
国别省市：德国,DE