A preparation method of calcium phosphate glass ceramics drug carrier, characterized in that it comprises the following steps: A) according to CaO: P: 2 O: 5: Na: 2 O: MgO: SrO molar ratio is 41.4 to 62: 9.80 to 46: 3.5 to 7: 1.5 to 3: 1.5 to 3 of its raw material grinding and mixing uniformly, from 1250 to 1350 DEG C melting 3 ~ 4 hours, quenching prepared transparent bulk bio glass, grinding and sieving, spare; B) the bioactive glass powder molding for the diameter of 20mm, thickness of 5mm wafer, in 650 ~ 780 degree centigrade ceramics processing, processing time is 4 ~ 12 hours, get the main phase Ca: 2 P: 2 O: 7 ceramics Glass; or in the 800 to 900 DEG C for 0.5 hours, get the main phase is Ca: 2 P: 2 O: 7, there is a small amount of strontium apatite Ca 2: Sr: 8 (PO: 4): 6 (OH): 2 and Ca: 9 NaMg (PO: 4) microcrystalline glass: 7; C) glass ceramics samples were soaked in HCl solution is 30 DEG C, 1mol / L in 12 ~ 24 hours, removed after rinsed with distilled water several times, Kong Guantong, the porosity of 40 ~ 67% porous glass ceramics.
【技术实现步骤摘要】
【技术保护点】
一种磷酸钙系微晶玻璃药物缓释载体的制备方法，其特征在于它包括以下步骤：Ａ）按ＣａＯ∶Ｐ↓［２］Ｏ↓［５］∶Ｎａ↓［２］Ｏ∶ＭｇＯ∶ＳｒＯ摩尔百分比为４１．４～６２∶９．８０～４６∶３．５～７∶１．５～３∶１．５～３将其原料研磨混合均匀，于１２５０～１３５０℃熔融３～４小时，淬冷制得透明块状生物玻璃，研磨过筛、备用；Ｂ）将上述生物玻璃粉末成型为直径Φ２０ｍｍ，厚５ｍｍ的圆片，在６５０～７８０℃进行微晶化处理，处理时间为４～１２小时，得到主晶相为Ｃａ↓［２］Ｐ↓［２］Ｏ↓［７］的微晶玻璃；或在８００～９００℃处理０．５小时，获得主晶相为Ｃａ↓［２］Ｐ↓［２］Ｏ↓［７］，还有少量锶磷灰石Ｃａ↓［２］Ｓｒ↓［８］（ＰＯ↓［４］）↓［６］（ＯＨ）↓［２］和Ｃａ↓［９］ＮａＭｇ（ＰＯ↓［４］）↓［７］的微晶玻璃；Ｃ）将微晶玻璃样品浸泡在３０℃、１ｍｏｌ／Ｌ的ＨＣｌ溶液中１２～２４小时，取出后用蒸馏水冲洗数次，得到孔贯通、孔隙率为４０～６７％的多孔微晶玻璃。
【技术特征摘要】
【专利技术属性】
技术研发人员：许国华，蔡舒，叶晓健，袁文，张喆，
申请(专利权)人：中国人民解放军第二军医大学，
类型：发明
国别省市：31
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